With Wales captain Dewi Leake ruled out of the first half of the Six Nations with a biceps injury and deputy hooker Ryan Elias recovering from a neck problem, Warren Gatland can hardly afford to lose any more of his senior players.
Wales will face France in its opening match on Friday, January 31.
Elliot Dee was due to make his first start of the Dragons campaign after an ankle injury, but an injury forced him to withdraw late.
Aaron Wainwright raised some concerns when he left the field in the 25th minute with a concussion, but returned after passing a head injury assessment. Rhodri Williams also suffered a knock late.
There were plenty of performances that would please Gatland, and Jack Morgan, who is likely to resume captaincy duties in Leek's absence, was once again a staunch Ospreys supporter.
Sam Barry, who left the national coaching squad in June in controversial circumstances, also showed his international pedigree.
Rhys Davies made a huge turnaround in his first appearance since March, while Dan Edwards continued to impress as a 10-year-old.
Cardiff's Teddy Williams was a nuisance in the line-up before receiving a yellow card, while Seb Davies also caught the eye.
Sam Costello pulled the strings for the Scarlets, Blair Murray showed his finishing prowess with two tries, while Josh McLeod led from the front.
Ryu Daer was once again a bright spark in the dragon's side.